DropPrev® HAP | Hydroxyacetophenone
DropPrev® HAP | Hydroxyacetophenone
DropPrev® HAP is a naturally derived ingredient with anti-corrosion, anti-bacterial, and antioxidant properties, making it a versatile and effective component in cosmetic formulations. It is found in the stems and leaves of marina artemisia and the roots of plants like artemisia capillaris and tylophora kerrii. DropPrev® HAP is known for its broad-spectrum antiseptic abilities, soothing effects, and excellent compatibility with other raw materials. It serves as an alternative to traditional preservatives, offering enhanced system stability.
INCI Name: Hydroxyacetophenone
Trade Name: DropPrev® HAP
CAS Number: 99-93-4
Chemical Formula: C8H8O2
Benefits
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Broad-Spectrum Antimicrobial Activity:
- Effectively inhibits common microbial strains including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, and Aspergillus brasiliensis.
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Antioxidant Protection:
- Neutralizes free radicals to protect formulations and maintain product efficacy.
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Soothing and Calming Effects:
- Reduces skin irritation, making it suitable for sensitive formulations.
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Formulation Stability:
- Enhances system stability by resisting microbial contamination without causing conflicts with other ingredients.
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Eco-Friendly and Gentle:
- A mild, non-irritating alternative to synthetic preservatives.
Suggested Usage
- Concentration: 0.1%–0.5%
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Applications:
- Emulsifying systems like creams and emulsions.
- Surfactant-based products such as cleansers and shampoos.
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Method of Incorporation:
- Add during the emulsification or cooling phase.
- Ensure proper mixing for uniform distribution.
Clinical Studies
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Antimicrobial Efficacy:
- MIC (Minimum Inhibitory Concentration) tests show effective inhibition of key microbial strains:
- Escherichia coli (EC): 0.25%
- Pseudomonas aeruginosa (PA): 0.25%
- Staphylococcus aureus (SA): 0.5%
- Candida albicans (CA): 0.25%
- Aspergillus brasiliensis (AB): 0.125%
- MIC (Minimum Inhibitory Concentration) tests show effective inhibition of key microbial strains:
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Skin Compatibility:
- Demonstrated excellent skin tolerance, making it suitable for sensitive skin products.
Cautions
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pH and Temperature Stability:
- Works effectively in formulations with a pH range of 4–8.
- Stable below 80°C; avoid excessive heat during processing.
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Storage:
- Keep sealed and store at room temperature, away from light and moisture.
Specification
- Appearance: White or off-white crystalline powder
- Assay (HPLC): ≥99.0%
- Melting Point: 108–110°C
- Water Content: ≤0.5%
- Heavy Metals (Pb): <20.0 mg/kg
- Residual Solvent: <0.02%
Packaging and Shelf Life
- Packaging: Provided in suitable sealed containers.
- Shelf Life: 2 years under recommended storage conditions.