DropPrev® CHA | Caprylhydroxamic Acid

DropPrev® CHA is an organic acid with potent anti-corrosion and antibacterial properties, specifically targeting molds like Aspergillus niger. Unlike many organic acids, it remains undissociated and highly effective across a neutral to acidic pH range, making it ideal for use as a preservative in cosmetics and personal care products. It acts through chelation of Fe²⁺ and Fe³⁺ in iron-restricted environments, limiting microbial growth while maintaining excellent skin compatibility.

INCI Name: Caprylhydroxamic Acid
CAS Number: 7377-03-9
Function: Anti-corrosion, Anti-bacterial

Benefits

1. Broad-Spectrum Bacteriostatic Activity:

   • Remains highly effective in neutral pH environments, ensuring long-lasting preservation.
   • Proven inhibitory effects against molds, especially Aspergillus niger, with an MIC of 780 ppm.

2. Chelation Effect:

   • Selectively chelates Fe²⁺ and Fe³⁺, restricting mold growth in iron-limited environments.
   • High stability of Fe³⁺ chelation prevents microbial proliferation effectively.

3. Enhanced Stability:

   • Maintains functionality in neutral pH formulations, outperforming other preservative alternatives.
   • Short-chain activity promotes microbial cell membrane degradation for effective preservation.

4. Safety and Versatility:

   • Extensively studied for use in humans and animals, demonstrating high safety levels.
   • Ideal for replacing traditional preservatives in cosmetic applications.

Suggested Usage

• Concentration: 0.05%–0.15%
• Applications:
  • Creams, lotions, and shampoos
  • Bath washes and facial masks
  • Wet tissues and makeup products
• Method of Incorporation:
  • Add during the emulsification or cool-down phase; temperature sensitivity is minimal.

Features

• Effective across neutral pH levels, ensuring consistent bacteriostatic performance.
• Optimal chain length (C8) for degrading microbial cell membranes effectively.
• Safe and stable for long-term use in formulations.

Physicochemical Properties

• Appearance: White crystalline powder
• Odor: Characteristic
• Purity (HPLC): ≥99.0%
• Melting Point: 78–81°C
• Volatile Matter: ≤0.5%
• Hydroxylamine Hydrochloride Value: ≤0.2%

Cautions

• Storage:

  • Store sealed at room temperature, away from light and moisture.
  • Avoid high humidity conditions to maintain stability.

• Solubility:

  • Slightly soluble in water; ensure proper formulation methods for uniform mixing.

Packaging and Shelf Life

• Packaging: Supplied in 25 kg barrels
• Shelf Life: 3 years under recommended storage conditions