DropBrigt® 4BR | 4-Butylresorcinol

DropBright® 4BR is a highly effective whitening and freckle-removing agent that significantly inhibits tyrosinase activity, the key enzyme in melanin synthesis. It operates through competitive inhibition and exhibits antioxidant properties, addressing pigmentation concerns such as melasma and other forms of hyperpigmentation. DropBright® 4BR works across multiple stages of melanin production, making it a potent solution for skin brightening and tone correction.

INCI Name: 4-Butylresorcinol
Trade Name: DropBright® 4BR
CAS Number: 18979-61-8
Function: Whitening, Freckle-removing
EWG Score: 1–2 (Low Hazard)

Benefits

1. Inhibits Tyrosinase Activity:

   • Acts as a competitive inhibitor by binding to the double copper ion at tyrosinase's active center, preventing melanin production.

2. Antioxidant Properties:

   • Counteracts oxidative stress in the early stages of melanin formation, reducing melanin by-products.

3. Comprehensive Whitening Action:

   • Before Melanin Synthesis: Prevents tyrosinase synthesis and glycosylation, reducing enzyme absorption by melanosomes.
   • During Melanin Synthesis: Inhibits tyrosinase and TRP1 enzyme activity, directly reducing melanin production.
   • After Melanin Synthesis: Enhances tyrosinase degradation, preventing melanocyte transfer to keratinocytes.

4. Protects Against Skin Damage:

   • Exhibits anti-glycosylation properties and protects DNA from damage induced by hydrogen peroxide (H₂O₂).

5. Targets Pigmentation Disorders:

   • Effective against melasma and pigmentation caused by sunlight exposure.

Suggested Usage

• Concentration: 0.1%–3.0%
• Applications:
  • Whitening and freckle-removal creams
  • Anti-aging lotions and essences
  • Skin-brightening serums
• Method of Incorporation:
  • Add during the formulation process; ensure uniform mixing.
  • Compatible with a wide range of cosmetic formulations.

Features

• Potent inhibitor of tyrosinase and peroxidase for effective whitening.
• Reduces pigment deposition and evens out skin tone.
• Strong antioxidant and anti-glycosylation effects.

Physicochemical Properties

• Appearance: White to almost white powder
• Odor: Characteristic odor
• Purity (HPLC): ≥98.0%
• Melting Point: 54–56°C
• Moisture Content (KF): ≤1.0%

Cautions

• Storage:

  • Store in a cool, dry, and well-ventilated place.
  • Keep the container tightly closed to avoid moisture exposure.

• Solubility:

  • Slightly soluble in water; ensure proper dissolution during formulation.

Packaging and Shelf Life

• Packaging: Available in 1 kg bags or 25 kg barrels.
• Shelf Life: 2 years under recommended storage conditions.