DropBrigt® AA2G | Ascorbyl Glucoside

DropBright® AA2G is a highly stable, water-soluble derivative of Vitamin C. By adding a glucose group to Vitamin C, AA2G overcomes the instability of pure Vitamin C, which is prone to oxidation when exposed to air or light. Upon enzymatic hydrolysis in the skin, it releases active Vitamin C, providing long-lasting whitening, antioxidant, and collagen-boosting benefits. Produced through an enzymatic fermentation process, it offers high efficiency and bioactivity at a low cost.

INCI Name: Ascorbyl Glucoside
CAS Number: 129499-78-1
Function: Whitening, Antioxidant, Collagen Booster
EWG Score: 1 (Low Hazard)

Benefits

1. Whitening and Brightening:

   • Inhibits tyrosinase activity and reduces melanin synthesis.
   • Converts dark melanin into lighter reductive melanin, visibly brightening skin tone.

2. Antioxidant Protection:

   • Scavenges free radicals like hydroxyl (OH) and superoxide anions (O2-), protecting the skin from oxidative stress.

3. Collagen Synthesis:

   • Stimulates fibroblast activity, enhancing collagen production for improved skin elasticity and wrinkle reduction.

4. Skin Repair and UV Protection:

   • Reduces DNA damage and alleviates skin injuries caused by sun exposure.

5. Gentle and Stable:

   • Offers higher stability and solubility than Vitamin C, making it suitable for sensitive formulations.

Suggested Usage

• Concentration: 0.5%–2.0%
• Applications:
  • Whitening serums and creams.
  • Anti-aging and repair formulations.
  • Sunscreens and post-sun exposure products.
• Method of Incorporation:
  • Dissolve in buffer or deionized water before adding to formulations.
  • Add below 55°C to preserve activity.
  • Optimal pH range: 5.0–7.0.

Features

• Stable against light, heat, and oxidation.
• Long-lasting whitening effects due to slow enzymatic conversion into Vitamin C.
• Bioavailable and non-irritating, suitable for sensitive skin.

Physicochemical Properties

• Appearance: White to off-white powder
• Assay (HPLC): ≥98.0%
• pH (1% Solution): 2.0–2.5
• Melting Point: 158–163°C
• Loss on Drying: ≤1.0%
• Heavy Metals (Pb): ≤10 ppm
• Arsenic (As): ≤1 ppm
• Free Vitamin C: ≤0.1%

Efficacy Studies

1. Melanin Reduction:

   • Inhibits tyrosinase activity by over 90% at a concentration of 16 mg/mL.

2. Antioxidant Efficiency:

   • Scavenges over 90% of DPPH free radicals (Brand-Williams Method).

3. Collagen Boosting:

   • Stimulates fibroblasts, increasing collagen production 3-fold with 0.25 mM AA2G in 24 days.

Cautions

• Storage:
  • Store at room temperature in a dark, sealed container to prevent degradation.
• Compatibility:
  • Avoid using with acid-sensitive raw materials.
  • Stabilize pH with a buffer system (e.g., citric acid and trisodium citrate).
  • Add EDTA-2Na or sodium bisulfite (0.02%–0.1%) to reduce discoloration risks.

Packaging and Shelf Life

• Packaging: 20 kg containers
• Shelf Life: 2 years under recommended storage conditions