DropBrigt® TAA | Tranexamic Acid

DropBright® TAA is a water-soluble whitening and anti-pigmentation agent known for its ability to effectively reduce melanin synthesis by blocking melanin production at its source. Originally used as a blood clotting agent, it was found to have significant skin-whitening effects when used to treat liver spots and melanomas. It has since become a popular ingredient for addressing pigmentation, improving rough skin, and reducing acne.

INCI Name: Tranexamic Acid
CAS Number: 1197-18-8
Function: Whitening, Anti-pigmentation, Anti-inflammatory
EWG Score: 1 (Low Hazard)

Benefits

1. Whitening and Freckle Removal:

   • Blocks melanin production at the source, addressing pigmentation caused by UV exposure.
   • 50 times more effective than Vitamin C and 10 times more effective than fruit acids at fading dark spots.

2. Anti-inflammatory and Skin Repair:

   • Reduces inflammation and protects sensitive skin.
   • Improves rough skin texture and reduces acne.

3. High Stability:

   • Maintains stability in neutral pH formulations.
   • Resistant to high temperatures and degradation.

Suggested Usage

• Concentration: 0.5%–3.0%
• Applications:
  • Whitening creams and serums
  • Anti-aging and freckle removal products
  • Sunscreen and pigmentation control products
• Method of Incorporation:
  • Recommended for neutral pH formulations.
  • Avoid the use of formaldehyde-releasing agents, as they can reduce Tranexamic Acid's content.

Features

• Water-soluble, colorless, and odorless.
• Synergizes well with other whitening agents for enhanced efficacy.
• Safe and effective in facial masks with no stinging or irritation.

Physicochemical Properties

• Appearance: Bright crystalline powder
• Assay: 99.0%–101.0%
• pH (1% Solution): 7.0–8.0
• Loss on Drying: ≤0.5%
• Impurities:
  • Impurity A: ≤0.1%
  • Impurity B: ≤0.2%
  • All other impurities: ≤0.2%
• Chlorides: ≤140 ppm
• Heavy Metals (Pb): ≤10 ppm

Efficacy Studies

• Skin Whitening (In Vivo):

  • Increased skin brightness (ITA˚) by 2.8 after 8 weeks at a 2% concentration.
  • Significant reductions in melanin index and pigmentation optical density compared to placebo.

• Anti-Pigmentation Results:

  • Melanin index reduced by 17.9 points in the test group after 8 weeks, compared to 5.4 in the placebo group.

Cautions

• Storage:
  • Store sealed in a cool, dry location, away from light and high temperatures.
• Solubility:
  • Poorly soluble in alcohol and acetone; highly soluble in water.

Packaging and Shelf Life

• Packaging: 1 kg bags, 25 kg buckets
• Shelf Life: 3 years under recommended storage conditions